Anti-inflammatory activity of doum palm fruit extract used in the management of benign prostatic hyperplasia

Abstract

Background: Benign prostatic hyperplasia (BPH) is a frequent health concern in men over the age of 50. It is characterized by an increase in the size of the prostate, which can lead to urinary issues. In the past, the treatment of BPH was limited to surgery. However, the introduction of drugs such as Permixon, based on saw palmetto extract, has revolutionized the management of this disease. This natural plant extract is effective in relieving the symptoms of BPH and can also slow the progression of the disease. The Algerian population consumes several plants for this purpose, such as nettle, galangal, pumpkin seeds, and doum palm. The doum palm (Chamaerops humilis) is a bushy plant with fan leaves that is widely distributed in the Mediterranean region. The terminal bud of this species is edible, however the doum palm has been appreciated by several societies throughout time for its multiple traditional uses and is primarily exploited for its fibers. In addition, this plant has aroused growing interest for its properties, especially in the treatment of benign prostatic hyperplasia. Aims: This study aimed to evaluate the in vitro anti-inflammatory activity of the aqueous extract of the doum palm by the protein denaturation method comparing it to Permixon extracts and corticosteroids in order to valorize this species and confirm its traditional use. Material and Methods: The fruits of Chamaerops humilis L. were dried, powdered, and extracted with aqueous water then screened by various chemical tests. The anti-inflammatory activity was estimated after dilution of each extract using the human serum albumin. Results: When evaluating the anti-inflammatory effect, we observed that the fruit extract exhibited significantly higher activity, with an IC₅₀ of 446,02 mg/mL, too close to that of Permixon (IC₅₀= 423.17 μg/mL) and exceeding that of corticosteroids (IC₅₀= 602,21 mg/mL). All three extracts clearly demonstrated their ability to reduce inflammation. Conclusion: The aqueous extract was found to be an effective anti-inflammatory agent. These results offer promising novel perspectives in the treatment of inflammation-related diseases, especially benign prostatic hyperplasia.

Keywords: anti-inflammatory activity, benign prostatic hyperplasia, doum palm, Permixon, secondary active metabolites.