Metabolic Syndrome Components Correlation with Colorectal Neoplasms: A Systematic Review and a Meta-Analysis

Salah Eddine  El Herrag; Youssouf  Traoré; Meghit Boumediene Khaled

doi:10.51745/najfnr.2.4.93-111

Metabolic Syndrome Components Correlation with Colorectal Neoplasms: A Systematic Review and a Meta-Analysis

PDF (Full text)

Human and Clinical Nutrition Nutrition, Metabolism, and Prevention of NCDs

DOI https://doi.org/10.51745/najfnr.2.4.93-111

Issue Vol. 2 No. 4 (2018): July - December: 2018

Submitted 2018-09-02

Published 2018-11-06

This work is licensed under a Creative Commons Attribution 4.0 International License.

Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Background: Patients with metabolic syndrome (MetS) have a higher risk of developing colorectal neoplasms (CRN) including colorectal adenoma (CRA) and colorectal cancer (CRC). Nonetheless, the role and implication of each component of the syndrome, i.e. (hyperglycemia, hypertension, dyslipidemia, and visceral obesity) are not well ascertained.

Aims: We conducted a systematic review and a meta-analysis in order to assess the association between MetS components and CRN.

Methods and Material: A systematic literature search using the PubMed database was performed with the objective of identifying relevant English studies. Effect estimates were measured. Heterogeneity, subgroup, sensitivity analyses, and publication bias analyses were performed.

Results: Thirty-one studies met our inclusion criteria. Generally, subjects with hyperglycemia (RR = 1.33; 95% CI 1.14-1.54), high waist circumference (RR = 1.30; 95% CI 1.19-1.42), high triglycerides (RR = 1.30; 95% CI 1.13-1.49), and hypertension (RR = 1.26; 95% CI 1.17-1.36) showed a stronger positive significant association with CRA formation risk. A similar pattern was found between high fasting blood glucose (RR = 1.35; 95% CI 1.23-1.47) and high blood pressure (RR = 1.28; 95% CI 1.20-1.37) with CRC incidence. A moderate association was found between hypertriglyceridemia and visceral obesity with CRC risk. Conversely, no significant association was found between low high-density lipoprotein-cholesterol (HDL-C) with both outcomes.

Conclusions: Our results indicate that hyperglycemia, hypertension, visceral obesity, and hypertriglyceridemia increases CRA and CRC risk. Low HDL-C has no significant effect on those outcomes.

Keywords

Colorectal Neoplasms Hyperglycemia Hypertension Visceral Obesity Dyslipidemia Meta-Analysis

Salah Eddine El Herrag

Djillali Liabes University, Faculty of Natural and Life Sciences, Department of Biology, Sidi-Bel-Abbes
Youssouf Traoré

Djillali Liabes University, Faculty of Natural and Life Sciences, Department of Biology, Sidi-Bel-Abbes
Meghit Boumediene Khaled

Djillali Liabes University, Faculty of Natural and Life Sciences, Department of Biology, Sidi-Bel-Abbes

How to Cite

El Herrag, S. E. ., Traoré, Y. ., & Khaled, M. B. (2018). Metabolic Syndrome Components Correlation with Colorectal Neoplasms: A Systematic Review and a Meta-Analysis. The North African Journal of Food and Nutrition Research, 2(4), 93-111. https://doi.org/10.51745/najfnr.2.4.93-111

More Citation Formats

Download Citation

1. Inoue K, Maeda N, Funahashi T. Metabolic Syndrome. In: Lammert E, Zeeb M, eds. Metabolism of Human Diseases: Organ Physiology and Pathophysiology. Vienna: Springer Vienna; 2014:199-203. doi:10.1007/978-3-7091-0715-7_30

2. The International Diabetes Federation (IDF). IDF Consensus Worldwide Definition of the Metabolic Syndrome. https://idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-the-metabolic-syndrome. Published 2006. Accessed July 17, 2017.

3. Kaur J. A Comprehensive Review on Metabolic Syndrome. Cardiol Res Pract. 2014;2014:e943162. doi:10.1155/2014/943162

4. Sorrentino MJ. The Metabolic Syndrome. In: Sorrentino MJ, ed. Hyperlipidemia in Primary Care: A Practical Guide to Risk Reduction. Totowa, NJ: Humana Press; 2011:13-39. doi:10.1007/978-1-60327-502-6_2

5. LeRoith D, Vinik AI, eds. Controversies in Treating Diabetes. Totowa, NJ: Humana Press; 2008. doi:10.1007/978-1-59745-572-5

6. Nolan JJ, O’Gorman DJ. Pathophysiology of the Metabolic Syndrome. In: Beck-Nielsen H, ed. The Metabolic Syndrome: Pharmacology and Clinical Aspects. Vienna: Springer Vienna; 2013:17-42. doi:10.1007/978-3-7091-1331-8_3

7. Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, van de Velde CJH, Watanabe T. COLORECTAL CANCER. Nat Rev Dis Primer. 2015;1:15065. doi:10.1038/nrdp.2015.65

8. Graham DM, Coyle VM, Kennedy RD, Wilson RH. Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer. Curr Colorectal Cancer Rep. 2016;12(3):141-150. doi:10.1007/s11888-016-0312-y

9. Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, de Braud F, Wils J. Colon cancer. Crit Rev Oncol Hematol. 2010;74(2):106-133. doi:10.1016/j.critrevonc.2010.01.010

10. Vipperla K, O’Keefe SJ. Colorectal Cancer. In: Lammert E, Zeeb M, eds. Metabolism of Human Diseases. Vienna: Springer Vienna; 2014:149-154. doi:10.1007/978-3-7091-0715-7_24

11. Jenab-Wolcott J, Giantonio B. Cancers of the Rectum and Anal Canal. In: Sepulveda AR, Lynch JP, eds. Molecular Pathology of Neoplastic Gastrointestinal Diseases. Vol 7. Boston, MA: Springer US; 2013:141-171. doi:10.1007/978-1-4614-6015-2_9

12. Parsyan A, Robichaud N, Meterissian S. Colorectal Cancers. In: Parsyan A, ed. Translation and Its Regulation in Cancer Biology and Medicine. Springer Netherlands; 2014:593-610. doi:10.1007/978-94-017-9078-9_29

13. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012: Globocan 2012. Int J Cancer. 2015;136(5):E359-E386. doi:10.1002/ijc.29210

14. Colussi D, Brandi G, Bazzoli F, Ricciardiello L. Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention. Int J Mol Sci. 2013;14(8): 16365-16385. doi:10.3390/ijms140816365

15. Moore JS, Aulet TH. Colorectal Cancer Screening. Adv Colorectal Neoplasia. 2017;97(3):487-502. doi:10.1016/j.suc.2017.01.001

16. Chu KM. 1 - Epidemiology and Risk Factors of Colorectal Cancer A2 - Gearhart, Susan L. In: Ahuja N, ed. Early Diagnosis and Treatment of Cancer Series: Colorectal Cancer. Saint Louis: W.B. Saunders; 2011:1-11. doi:10.1016/B978-1-4160-4686-8.50006-3

17. Johnson CM, Wei C, Ensor JE, Smolenski DJ, Amos CI, Levin B, Berry DA. Meta-analyses of colorectal cancer risk factors. Cancer Causes Control. 2013;24(6):1207-1222. doi:10.1007/s10552-013-0201-5

18. Aran V, Victorino AP, Thuler LC, Ferreira CG. Colorectal Cancer: Epidemiology, Disease Mechanisms and Interventions to Reduce Onset and Mortality. Clin Colorectal Cancer. 2016;15(3):195-203. doi:10.1016/j.clcc.2016.02.008

19. Carrer A, Giacca M, Giacca M. Molecular Parameters for Prognostic and Predictive Assessment in Colorectal Cancer. In: de Manzini N, ed. Rectal Cancer. Milano: Springer Milan; 2013:41-62. doi:10.1007/978-88-470-2670-4_4

20. Tan CH, Das P, Silberfein EJ, Rodriguez-Bigas M, Iyer RB. Chapter 17 - Colorectal Cancer A2 - Silverman, Paul M. In: Oncologic Imaging: A Multidisciplinary Approach. Philadelphia: W.B. Saunders; 2012:267-286. doi:10.1016/B978-1-4377-2232-1.00017-6

21. Jess T, Rungoe C, Peyrin–Biroulet L. Risk of Colorectal Cancer in Patients with Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies. Clin Gastroenterol Hepatol. 2012; 10 (6): 639-645. doi:10.1016/j.cgh.2012.01.010

22. Godos J, Bella F, Torrisi A, Sciacca S, Galvano F, Grosso G. Dietary patterns and risk of colorectal adenoma: a systematic review and meta-analysis of observational studies. J Hum Nutr Diet. 2016;29(6):757-767. doi:10.1111/jhn.12395

23. Zhu B, Sun Y, Qi L, Zhong R, Miao X. Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies. Sci Rep. 2015;5:8797. doi:10.1038/srep08797

24. Vieira AR, Abar L, Chan D, Vingeliene S, Polemiti E, Stevens C, Greenwood D, Norat T. Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project. Ann Oncol Off J Eur Soc Med Oncol. April 2017. doi:10.1093/annonc/mdx171

25. Zhou X-Y, Yan L, Wang L-L, Wang J. Association between physical activity and colorectal cancer risk and prognosis: A meta-analysis. Cancer Treat Res Commun. 2016; 9: 62-69. doi:10.1016/j.ctarc.2016.07.002

26. Tsoi KKF, Pau CYY, Wu WKK, Chan FKL, Griffiths S, Sung JJY. Cigarette Smoking and the Risk of Colorectal Cancer: A Meta-analysis of Prospective Cohort Studies. Clin Gastroenterol Hepatol. 2009;7(6):682-688.e5. doi:10.1016/j.cgh.2009.02.016

27. Kort S de, Masclee AAM, Sanduleanu S, Weijenberg MPP, Herk-Sukel MP, Oldenhof NJJ, Bergh JPW, Haak HR, Janssen-Heijnen ML. Higher risk of colorectal cancer in patients with newly diagnosed diabetes mellitus before the age of colorectal cancer screening initiation. Sci Rep. 2017; 7: 46527. doi:10.1038/srep46527

28. Esposito K, Chiodini P, Capuano A, Bellastella G, Maiorino MI, Rafaniello C, Panagiotakos DB, Giugliano D. Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis. Endocrine. 2013; 44 (3): 634-647. doi:10.1007/s12020-013-9939-5

29. Stocks T, Lukanova A, Bjørge T, Ulmer H, Manjer J, Almquist M, Concin H, Engeland A, Hallmans G, Nagel G, Tretli S, Veierød MB, Jonsson H, Stattin P. Metabolic factors and the risk of colorectal cancer in 580,000 men and women in the metabolic syndrome and cancer project (Me-Can). Cancer. 2011;117(11):2398-2407. doi:10.1002/cncr.25772

30. Jinjuvadia R, Lohia P, Jinjuvadia C, Montoya S, Liangpunsakul S. The Association between Metabolic Syndrome and Colorectal Neoplasm: Systemic review and Meta-analysis. J Clin Gastroenterol. 2013;47(1):33-44. doi:10.1097/MCG.0b013e3182688c15

31. Moher D, Liberati A, Tetzlaff J, Altman DG, Group TP. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLOS Med. 2009;6(7): e1000097. doi:10.1371/journal.pmed.1000097

32. Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed August 18, 2018.

33. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1(2):97-111. doi:10.1002/jrsm.12

34. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557. doi:10.1136/bmj.327.7414.557

35. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-1558. doi:10.1002/sim.1186

36. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629-634. doi:10.1136/bmj.315.7109.629

37. Begg CB, Mazumdar M. Operating Characteristics of a Rank Correlation Test for Publication Bias. Biometrics. 1994;50(4):1088-1101. doi:10.2307/2533446

38. Duval Sue, Tweedie Richard. Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis. Biometrics. 2004;56(2):455-463. doi:10.1111/j.0006-341X.2000.00455.x

39. Review Manager (RevMan). Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2014. https://community.cochrane.org

40. Viechtbauer Wolfgang, Cheung Mike W.-L. Outlier and influence diagnostics for meta-analysis. Res Synth Methods. 2010;1(2):112-125. doi:10.1002/jrsm.11

41. Baujat Bertrand, Mahé Cédric, Pignon Jean-Pierre, Hill Catherine. A graphical method for exploring heterogeneity in meta-analyses: application to a meta-analysis of 65 trials. Stat Med. 2002;21(18):2641-2652. doi:10.1002/sim.1221

42. R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2018. https://www.R-project.org/.

43. Viechtbauer W. Conducting Meta-Analyses in R with the metafor Package. J Stat Softw Vol 1 Issue 3 2010. August 2010. https://www.jstatsoft.org/v036/i03.

44. Lin X-F, Shi K-Q, You J, Liu WY, Luo YW, Wu FL, Chen YP, Chen DKH, Yuen MF, Zheng MH. Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study. Mol Biol Rep. 2014;41(5):2989-2997. doi:10.1007/s11033-014-3157-y

45. Huang K-W, Leu H-B, Wang Y-J, Luo JC, Lin HC, Lee FY, Chan WL, Lin JK, Chang FY. Patients with nonalcoholic fatty liver disease have higher risk of colorectal adenoma after negative baseline colonoscopy. Colorectal Dis Off J Assoc Coloproctology G B Irel. 2013;15(7):830-835. doi:10.1111/codi.12172

46. Kim BC, Shin A, Hong CW, Sohn DK, Han KS, Ryu KH, Park BJ, Nam JH, Park JW, Chang HJ, Choi HS, Kim J, Oh JH. Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control CCC. 2012;23(5):727-735. doi:10.1007/s10552-012-9942-9

47. Bowers K, Albanes D, Limburg P, Pietinen P, Taylor PH, Virtamo J, Stolzenberg-Solomon R. A Prospective Study of Anthropometric and Clinical Measurements Associated with Insulin Resistance Syndrome and Colorectal Cancer in Male Smokers. Am J Epidemiol. 2006;164(7):652-664. doi:10.1093/aje/kwj253

48. Kabat GC, Kim MY, Peters U, Stefanick M, Hou L, Wactawski-Wende J, Messina C, Shikany JM, Rohan TE. A Longitudinal Study of the Metabolic Syndrome and Risk of Colorectal Cancer in Postmenopausal Women. Eur J Cancer Prev Off J Eur Cancer Prev Organ ECP. 2012;21(4):326-332. doi:10.1097/CEJ.0b013e32834dbc81

49. Liang X, Margolis KL, Hendryx M, Rohan T, Groessl EJ, Thomson CA, Kroenke CH, Simon M, Lane D, Stefanick M, Luo J. Metabolic phenotype and risk of colorectal cancer in normal-weight postmenopausal women. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2017;26(2):155-161. doi:10.1158/1055-9965.EPI-16-0761

50. Shin CM, Han K, Lee DH, Choi YJ, Kim N, Park YS, Yoon H. Association Among Obesity, Metabolic Health, and the Risk for Colorectal Cancer in the General Population in Korea Using the National Health Insurance Service–National Sample Cohort. Dis Colon Rectum. 2017;60(11):1192–1200. doi:10.1097/DCR.0000000000000876

51. Shapero TF, Chen GI, Devlin T, Gibbs A, Murray IC, Tran S, Weigensberg C. Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study. Can J Gastroenterol Hepatol. 2017;2017:8750967. doi:10.1155/2017/8750967

52. Stocks T, Lukanova A, Johansson M, Rinaldi S, Palmqvist R, Hallmans G, Kaaks R, Stattin P. Components of the metabolic syndrome and colorectal cancer risk; a prospective study. Int J Obes. 2007;32:304. doi:10.1038/sj.ijo.0803713

53. Pyo JH, Hong SN, Min B-H, Lee JH, Chang DK, Rhee PL, Kim JJ, Choi SK, Jung SH, Son HJ, Kim YH. Evaluation of the risk factors associated with rectal neuroendocrine tumors: a big data analytic study from a health screening center. J Gastroenterol. 2016;51(12):1112-1121. doi:10.1007/s00535-016-1198-9

54. Jeon YJ, Kim JW, Park HM, Jang HG, Kim JO, Oh J, Chong SY, Kwon SW, Kim EJ, Oh D, Kim NK. Interplay between 3′-UTR polymorphisms in the vascular endothelial growth factor (VEGF) gene and metabolic syndrome in determining the risk of colorectal cancer in Koreans. BMC Cancer. 2014;14:881. doi:10.1186/1471-2407-14-881

55. Kontou N, Psaltopoulou T, Soupos N, Polychronopoulos E, Xinopoulos D, Linos A, Panagiotakos DB. Metabolic syndrome and colorectal cancer: the protective role of Mediterranean diet--a case-control study. Angiology. 2012;63(5):390-396. doi:10.1177/0003319711421164

56. Aleksandrova K, Boeing H, Jenab M, Bas Bueno-de-Mesquita H, Jansen E, van Duijnhoven FBJ, Fedirko V, Rinaldi S, Romieu I, Riboli E, Romaguera D, Overvad K, Østergaard JN, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Morois S, Masala G, Agnoli C, Panico S, Tumino R, Vineis P, Kaaks R, Lukanova A, Trichopoulou A, Naska A, Bamia C, Peeters PH, Rodríguez L, Buckland G, Sánchez MJ, Dorronsoro M, Huerta JM, Barricarte A, Hallmans G, Palmqvist R, Khaw KT, Wareham N, Allen NE, Tsilidis KK, Pischon T. Metabolic Syndrome and Risks of Colon and Rectal Cancer: The European Prospective Investigation into Cancer and Nutrition Study. Cancer Prev Res (Phila Pa). 2011;4(11):1873. doi:10.1158/1940-6207.CAPR-11-0218

57. Shen Z, Wang S, Ye Y, Yin M, Yang X, Jiang K, Liu Y. Clinical study on the correlation between metabolic syndrome and colorectal carcinoma. ANZ J Surg. 2010;80(5):331-336. doi:10.1111/j.1445-2197.2009.05084.x

58. Pelucchi C, Negri E, Talamini R, Levi F, Giacosa A, Crispo A, Bidoli E, Montella M, Franceschi S, La Vecchia C. Metabolic syndrome is associated with colorectal cancer in men. Eur J Cancer. 2010;46(10):1866-1872. doi:10.1016/j.ejca.2010.03.010

59. Kang HW, Kim D, Kim HJ, Kim C, Kim YS, Park MJ, Kim JS, Cho SH, Sung MW, Jung HC, Lee HS, Song IS. Visceral Obesity and Insulin Resistance as Risk Factors for Colorectal Adenoma: A Cross-Sectional, Case–Control Study. Am J Gastroenterol. 2009;105(1):178-187. doi:10.1038/ajg.2009.541

60. Fliss‐Isakov Naomi, Zelber‐Sagi Shira, Webb Muriel, Halpern Zamir, Shibolet Oren, Kariv Revital. Distinct Metabolic Profiles are Associated with Colorectal Adenomas and Serrated Polyps. Obesity. 2017;25(S2):S72-S80. doi:10.1002/oby.22001

61. Harima S, Hashimoto S, Shibata H, Matsunaga T, Tanabe R, Terai S, Sakaida I. Correlations between Obesity/ Metabolic Syndrome-Related Factors and Risk of Developing Colorectal Tumors. Hepato-gastroenterology hge. 2013: 733-737. doi:10.5754/hge12895

62. Lipka S, Zheng XE, Hurtado-Cordovi J, Singh J, Levine E, Vlacancich R, Krishnamachari B, Jung MK, Fu S, Takeshige U, Avezbakiyev B, Li T, Iqbal J, Rizvon K, Mustacchia P. Obesity, Metabolic Factors, and Colorectal Adenomas: a Retrospective Study in a Racially Diverse New York State Hospital. J Gastrointest Cancer. 2013;44(3):270-276. doi:10.1007/s12029-013-9476-8

63. Morita T, Tabata S, Mineshita M, Mizoue T, Moore MA, Kono S. The Metabolic Syndrome is Associated with Increased Risk of Colorectal Adenoma Development: The Self-Defense Forces Health Study. APJCP. 2005;6(4):5. http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:16435997&key=2005.6.4.485

64. Tsilidis KK, Brancati FL, Pollak MN, Rifai N, Clipp SL, Hoffman-Bolton J, Helzlsouer KJ, Platz EA. Metabolic syndrome components and colorectal adenoma in the CLUE II cohort. Cancer Causes Control CCC. 2010;21(1):1-10. doi:10.1007/s10552-009-9428-6

65. Hong SN, Lee TY, Yun S-C. The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases. J Korean Med Sci. 2015;30(9):1288-1294. doi:10.3346/jkms.2015.30.9.1288

66. Jung YS, Yun KE, Chang Y, Ryu S, Park JH, Kim HJ, Cho YK, Sohn I, Jeon WK, Kim BI, Park I. Risk factors associated with rectal neuroendocrine tumors: a cross-sectional study. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2014;23(7):1406-1413. doi:10.1158/1055-9965.EPI-14-0132

67. Lee CG, Hahn SJ, Song MK, Lee JK, Kim JH, Lim YJ, Koh MS, Lee JH, Kang HW. Vegetarianism as a Protective Factor for Colorectal Adenoma and Advanced Adenoma in Asians. Dig Dis Sci. 2014;59(5):1025-1035. doi:10.1007/s10620-013-2974-5

68. Sato T, Takeda H, Sasaki Y, Kawata S. Increased homeostasis model assessment-insulin resistance is a risk factor for colorectal adenoma in Japanese males. Tohoku J Exp Med. 2011;223(4):297-303. doi:10.1620/tjem.223.297

69. Hu N-C, Chen J-D, Lin Y-M, Chang J-Y, Chen Y-H. Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy. J Formos Med Assoc. 2011;110(2):100-108. doi:10.1016/S0929-6646(11)60016-8

70. Hong SN, Kim JH, Choe WH, Han HS, Sung IK, Park HS, Shim CS. Prevalence and risk of colorectal neoplasms in asymptomatic, average-risk screenees 40 to 49 years of age. Gastrointest Endosc. 2010;72(3):480-489. doi:10.1016/j.gie.2010.06.022

71. Hwang ST, Cho YK, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Won KH. Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. J Gastroenterol Hepatol. 2010;25(3):562-567. doi:10.1111/j.1440-1746.2009.06117.x

72. Oh T-H, Byeon J-S, Myung S-J, Yang SK, Choi KS, Chung JW, Kim B, Lee D, Byun JH, Jang SJ, Kim JH. Visceral obesity as a risk factor for colorectal neoplasm. J Gastroenterol Hepatol. 2008;23(3):411-417. doi:10.1111/j.1440-1746.2007.05125.x

73. Kim JH, Lim YJ, Kim Y-H, Sung IK, Shim SG, Oh SO, Park SS, Yang S, Son HG, Rhee PL, Kim JJ, Rhee JC, Choi YH. Is Metabolic Syndrome A Risk Factor for Colorectal Adenoma? Cancer Epidemiol Prev Biomark. 2007;16(8):1543-1546. doi:10.1158/1055-9965.EPI-07-0199

74. Yang SY, Kim YS, Lee JE, Seol J, Song JH, Chung GE, Yim JY, Lim SH, Kim JS. Dietary protein and fat intake in relation to risk of colorectal adenoma in Korean. Elrazek. AEA, ed. Medicine (Baltimore). 2016;95(49):e5453. doi:10.1097/MD.0000000000005453

75. Elherrag SE, Traoré Y, Khaled MB. Metabolic Syndrome and Risk of Colorectal Adenoma and Colorectal Cancer: A Meta-Analysis. North Afr J Food Nutr Res. 2017;01(02):30-43. doi:10.5281/zenodo.1245604

76. World Health Organization. WHO | Obesity and overweight. WHO. http://www.who.int/mediacentre/factsheets/fs311/en/. Published October 2017. Accessed November 29, 2017.

77. Arnold M, Leitzmann M, Freisling H, Bray F, Romieu I, Renehan A, Soerjomataram I. Obesity and cancer: An update of the global impact. Cancer Epidemiol. 2016;41(Supplement C):8-15. doi:10.1016/j.canep.2016.01.003

78. González Svatetz CA, Goday Arnó A. Obesity and cancer: “Dangerous friendship.” Med Clínica Engl Ed. 2015;145(1):24-30. doi:10.1016/j.medcle.2014.05.011

79. Ma Y, Yang Y, Wang F, Zhang P, Shi C, Zou Y, Qin H. Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies. PLOS ONE. 2013;8(1):e53916. doi:10.1371/journal.pone.0053916

80. Zhang X, Wu WKK, Yu J. Obesity and Cancer. In: Ahmad SI, Imam SK, eds. Obesity: A Practical Guide. Cham: Springer International Publishing; 2016:211-220. doi:10.1007/978-3-319-19821-7_16

81. Suchanek S, Grega T, Ngo O, Vojtechova G, Majek O, Minarikova P, Brogyuk N, Bunganic B, Seifert B, Dusek L Zavoral M. How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia? World J Gastroenterol. 2016;22(36):8103-8111. doi:10.3748/wjg.v22.i36.8103

82. Mendonça FM, de Sousa FR, Barbosa AL, Martins SC, Araújo RL, Soares R, Abreu C. Metabolic syndrome and risk of cancer: Which link? Metabolism. 2015;64(2):182-189. doi:10.1016/j.metabol.2014.10.008

83. Pais R, Silaghi H, Silaghi AC, Rusu ML, Dumitrascu DL. Metabolic syndrome and risk of subsequent colorectal cancer. World J Gastroenterol WJG. 2009;15(41):5141-5148. doi:10.3748/wjg.15.5141

84. Ishino K, Mutoh M, Totsuka Y, Nakagama H. Metabolic syndrome: a novel high-risk state for colorectal cancer. Cancer Lett. 2013;334(1):56-61. doi:10.1016/j.canlet.2012.10.012

85. Erbach M, Mehnert H, Schnell O. Diabetes and the risk for colorectal cancer. J Diabetes Complications. 2012;26(1):50-55. doi:10.1016/j.jdiacomp.2011.11.003

86. Eibl G, Cruz-Monserrate Z, Korc M, Petrov MS, Goodarzi MO, Fisher WE, Habtezion A, Lugea A, Pandol SJ, Hart PA, Andersen DK. Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. J Acad Nutr Diet. September 2017. doi:10.1016/j.jand.2017.07.005

87. Zelenko Z, Gallagher EJ. Diabetes and Cancer. Diabetes Mellit Assoc Cond. 2014;43(1):167-185. doi:10.1016/j.ecl.2013.09.008

88. Smith LA, O’Flanagan CH, Bowers LW, Allott EH, Hursting SD. Translating Mechanism-Based Strategies to Break the Obesity−Cancer Link: A Narrative Review. J Acad Nutr Diet. November 2017. doi:10.1016/j.jand.2017.08.112

89. Niwa Y, Ishikawa K, Ishigami M, Honda T, Achiwa K, Izumoto T, Maekawa R, Hosokawa K, Iida A, Seino Y, Hamada Y, Goto H, Oiso Y, Arima H, Tsunekawa S. Effect of hyperglycemia on hepatocellular carcinoma development in diabetes. Biochem Biophys Res Commun. 2015;463(3):344-350. doi:10.1016/j.bbrc.2015.05.066

90. Shi J, Xiong L, Li J, Cao H, Jiang W, Liu B, Chen X, Liu C, Liu K, Wang G, Cai K. A Linear Dose-Response Relationship between Fasting Plasma Glucose and Colorectal Cancer Risk: Systematic Review and Meta-analysis. Sci Rep. 2015;5:17591. doi:10.1038/srep17591

91. Boffetta P, Boccia S, La Vecchia C. A Quick Guide to Cancer Epidemiology. Cham: Springer International Publishing; 2014. doi:10.1007/978-3-319-05068-3

92. Yaturu S, Fort C. Prostate cancer is associated with the metabolic syndrome. J Mens Health. 2009;6(2):125-129. doi:10.1016/j.jomh.2009.01.005

93. Largent JA, Bernstein L, Horn-Ross PL, Marshall SF, Neuhausen S, Reynolds P, Ursin G, Zell JA, Ziogas A, Anton-Culver H. Hypertension, antihypertensive medication use, and breast cancer risk in the California Teachers Study cohort. Cancer Causes Control. 2010;21(10):1615-1624. doi:10.1007/s10552-010-9590-x

94. Tian Y, Wang K, Li J, Wang J, Wang Z, Fan Y, Ye Y, Ji G, Li Y. The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis. Public Health Nutr. 2015;18(18):3355-3370. doi:10.1017/S1368980015000646

95. Yao X, Tian Z. Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies. Cancer Causes Control CCC. 2015;26(2):257-268. doi:10.1007/s10552-014-0507-y

96. Agnoli C, Grioni S, Sieri S, Sacerdote C, Vineis P, Tumino R, Giurdanella MC, Pala V, Mattiello A, Chiodini P, Iacoviello L, De Curtis A, Cattaneo L, van Duijnhoven FGB, Panico S, Krogh V. Colorectal cancer risk and dyslipidemia: A case–cohort study nested in an Italian multicentre cohort. Cancer Epidemiol. 2014;38(2):144-151. doi:10.1016/j.canep.2014.02.002

97. Siddiqui AA, Palmer BF. Metabolic Syndrome and Its Association With Colorectal Cancer: A Review. Am J Med Sci. 341(3):227-231. doi:10.1097/MAJ.0b013e3181df9055

98. Lipscombe L. Insulin, Insulin Resistance, and Cancer Associations. In: Fantus IG, ed. Insulin Resistance and Cancer: Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications. New York, NY: Springer New York; 2011:111-140. doi:10.1007/978-1-4419-9911-5_5

99. Chen Y, Wen Y, Li Z, Luo D, Zhang X. The molecular mechanisms between metabolic syndrome and breast cancer. Biochem Biophys Res Commun. 2016;471(4):391-395. doi:10.1016/j.bbrc.2016.02.034

100. Kucharska-Newton AM, Rosamond WD, Schroeder JC, McNeill AM, Coresh J, Folsom AR. HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study. Lung Cancer. 2008;61(3):292-300. doi:10.1016/j.lungcan.2008.01.015

101. Kucharska-Newton AM, Rosamond WD, Mink PJ, Alberg AJ, Shahar E, Folsom AR. HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study. Ann Epidemiol. 2008;18(9):671-677. doi:10.1016/j.annepidem.2008.06.006

102. Osaki Y, Taniguchi S, Tahara A, Okamoto M, Kishimoto T. Metabolic syndrome and incidence of liver and breast cancers in Japan. Cancer Epidemiol. 2012;36(2):141-147. doi:10.1016/j.canep.2011.03.007

103. Lu C-W, Lo Y-H, Chen C-H, Lin CY, Tsai CH, Chen PJ, Yang YF, Wang CH, Tan CH, Hou MF, Yuan SF. VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis. Cancer Lett. 2017;388(Supplement C):130-138. doi:10.1016/j.canlet.2016.11.033

More

Most read articles by the same author(s)

Djihane Bouledroua, Hajer Debbabi, Meghit Boumediene Khaled, Hanen Ben Ismail, Sarra Jribi, Darine Doggui, Dorra Sfayhi Understanding Bread Consumption and Waste Patterns in Algeria and Tunisia: Insights into Consumer Practices and Challenges
Meghit Boumediene Khaled, Nada Benajiba The Role of Nutrition in Strengthening Immune System Against Newly Emerging Viral Diseases: Case of SARS-CoV-2
Mohammed Amine Chami, Meghit Boumediene Khaled Epidemiology, diagnosis, and assessment of diabetes mellitus in the elderly population: a purposive review
Mustapha Diaf, Meghit Boumediene Khaled Overview on Main Nutrition-Related Diseases in Three Countries from North Africa
Djihane Bouledroua, Hajer Debbabi, Meghit Boumediene Khaled, Hanen Ben Ismail, Sarra Jribi, Darine Doggui, Dorra Sfayhi-Terras From Storage to Disposal: An Investigation of Household Bread Management and Waste in Algeria and Tunisia
Meghit Boumediene Khaled, Mustapha Diaf Predatory Journals and Publishers at a Glance: Take Apart or Take Over?
Kaddour Ziani, Fatima Idriss Khodja, Meghit Boumediene Khaled Physicochemical Quality Assessment of Brazilian Frozen Beef Imported Into Algeria
Salah Eddine El Herrag, Youssouf Traoré, Meghit Boumediene Khaled Metabolic Syndrome and Risk of Colorectal Adenoma and Colorectal Cancer: A Meta-Analysis
Amina Tires, Mustapha Diaf, Bakhta Bouzouira, Meghit Boumediene Khaled Ameliorative Effects of Citrus aurantium Juice on Metabolic Disorders Induced by Trans Fatty Acid-Rich Amalgam in Wistar rats
Bachir Benarba, Meghit Boumediene Khaled New Insight on Nutrition and COVID-19 Pandemic

1 2 > >>

Downloads 787

-

Views 1886

-

Metabolic Syndrome Components Correlation with Colorectal Neoplasms: A Systematic Review and a Meta-Analysis

Keywords

How to Cite

Similar Articles

Most read articles by the same author(s)

Downloads 787

Views 1886

Country (Top 10)

Make a Submission

Journal Issue

Keywords

Browse by Category

Information

Highly Accessed

Published by

Useful Links

Connect

Contact Us