Anticarcinogenic and antioxidant activities of leaves and flowers hydroalcoholic extracts of Nerium oleander L.: PCA analysis and phytochemical content by FTIR spectroscopy

Siham Ayouaz (1) , Izabela Koss-Mikołajczyk (2) , Nawel Adjeroud- Abdellatif (3) , Agnieszka Bartoszek (4) , Radia Arab (5) , Khokha Mouhoubi (6) , Dimas Rahadian Aji Muhammad (7) , Dwi Larasatie Nur (8) , Khodir Madani (9)
(1) Laboratoire Biomathématiques Biophysique Biochimie et de Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia , Algeria
(2) Department of Food Chemistry, Technology and Biotechnology, Gdańsk University of Technology, 11/12 Narutowicza St , Poland
(3) Laboratoire Biomathématiques Biophysique Biochimie et de Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia. Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia , Algeria
(4) Department of Food Chemistry, Technology and Biotechnology, Gdańsk University of Technology, 11/12 Narutowicza St , Poland
(5) Laboratoire Biomathématiques Biophysique Biochimie et de Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia , Algeria
(6) Centre de Recherche en Technologies Agro-alimentaires (CRTAA), Campus universitaire Targua Ouzemour. Bejaia. 06000 , Algeria
(7) Department of Food Science and Technology, Faculty of Agriculture, Universitas Sebelas Maret, Jl. Ir Sutami 36A Surakarta, 57126 , Indonesia
(8) Department of Food Science and Technology, Faculty of Agriculture, Universitas Sebelas Maret, Jl. Ir Sutami 36A Surakarta, 57126 , Indonesia
(9) Laboratoire Biomathématiques Biophysique Biochimie et de Scientométrie (L3BS), Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia. Centre de Recherche en Technologies Agro-alimentaires (CRTAA), Campus universitaire Targua Ouzemour. Bejaia. 06000 , Algeria

Abstract

Aims: The aim of this work is the evaluation the anticarcinogenic effect on HT29 cancer cells lines and antioxidant effect of three extracts from different morphological parts (leaves (LE), pink flowers (PFE) and white flowers (WFE)) of Nerium oleander lin. Methods: This research provides the anticarcinogenic activity of extracts from N. oleander white flowers. Principal Component Analysis (PCA) was applied to estimate the relationship between antioxidant and anticarcinogenic activities, and to further understand the similarities and differences between the extracts. Results: All of the extracts exhibited different antioxidant (ABTS, DPPH and FC) and anticarcinogenic activities. FTIR analysis designed the existence of various functional groups in extracts confirming the presence of alcohol, alkanes, amino, aromatic compound and primary alcohol. The PCA results show that the WFE extract exhibits a greater antioxidant activity with a potent potential for inhibiting the cell growth of colorectal cancer HT29 than the two other extracts (LE and PFE). Conclusions: Nerium oleander may therefore be an excellent source of natural antioxidant and anticancer agents, as well as a possible pharmaceutical supplement.

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Authors

Siham Ayouaz
siham.ayouaz@univ-bejaia.dz (Primary Contact)
Izabela Koss-Mikołajczyk
Nawel Adjeroud- Abdellatif
Agnieszka Bartoszek
Radia Arab
Khokha Mouhoubi
Dimas Rahadian Aji Muhammad
Dwi Larasatie Nur
Khodir Madani
Ayouaz, S., Koss-Mikołajczyk, I. ., Adjeroud- Abdellatif, N. ., Bartoszek, A. ., Arab, R. . ., Mouhoubi, K., Rahadian Aji Muhammad, D. ., Larasatie Nur , D. ., & Madani, K. . (2023). Anticarcinogenic and antioxidant activities of leaves and flowers hydroalcoholic extracts of Nerium oleander L.: PCA analysis and phytochemical content by FTIR spectroscopy. The North African Journal of Food and Nutrition Research, 7(15), 1–8. https://doi.org/10.51745/najfnr.7.15.1-8

Article Details

Received 2022-11-12
Accepted 2023-01-15
Published 2023-02-24

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