Predictive Equations Overestimated the Rest Energy Expenditure by Indirect Calorimetry in Adults with Sickle Cell Disease

Authors

  • Karen Cordovil Pós-Graduação em Ciências Médicas, Universidade do Estado do Rio de Janeiro https://orcid.org/0000-0003-1573-7796
  • Marise Crivelli Universidade do Estado do Rio de Janeiro
  • Larissa Calixto Lima Universidade do Estado do Rio de Janeiro
  • Flavia S. Barbosa Universidade do Estado do Rio de Janeiro
  • Marcos Fleury Universidade Federal do Rio de Janeiro

DOI:

https://doi.org/10.51745/najfnr.6.14.94-106

Keywords:

sickle cell disease, energy expenditure, prediction equations, body composition, hemolysis

Abstract

Background: Traditionally, hypermetabolism is described in sickle cell disease (SCD). Despite this, few studies have compared rest energy expenditure (REE) with estimated by predictive equations (EEE) in the assessment of adults with SCD. Aims:  To compare REE values determined by indirect calorimetry (IC) with that EEE in adults with SCD. Subjects and Methods: A cross-sectional observational study was performed with 46 individuals over 34 years old in the treatment from two reference centers for SCD located in the city of Rio de Janeiro, Brazil. The dual-energy X-ray absorptiometry (DXA) and IC  were used to assess BC and REE, respectively. Blood levels were measured to assess hemolytic and protein markers. Pearson’s correlation test was used in the univariate correlation. The Intraclass Correlation Coefficient (ICC) and the Bland-Altman analysis were used in the comparison between EEE and IC. P-values ≤ 0.05 were considered statistically significant. Results: Most participants were from the female sex, Hb SS genotype (80.4%) and with black color (52.2%). The mean age was 50 years old. Weight (r= 0.469; p=0,001), LM (r = 0.631; p=0.000), BMC (r = 0.508; p=0.000) and CRP(r=0.319; p = 0.002) correlated positively with the REE. There was no linear correlation between makers of hemolysis with REE. The REE was overestimated in the EEE when compared to IC (p<0.001). Conclusions: The prediction equations developed for healthy populations are not accurate enough to determine the energy requirements and more studies are needed to better understand how REE role in middle-aged and elderly adults with SCD.

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Author Biographies

Marise Crivelli, Universidade do Estado do Rio de Janeiro

Universidade do Estado do Rio de Janeiro

Nutrition Institute

The Interdisciplinary Laboratory of Nutritional Assessment

São Francisco Xavier Street, 900, João Lyra Filho Pavilion, second floor - Maracanã, Rio de Janeiro – Rio de Janeiro, Brazil, Zip Code 20550-000.

Larissa Calixto Lima, Universidade do Estado do Rio de Janeiro

Universidade do Estado do Rio de Janeiro

Nutrition Institute

Postgraduate Program Feeding, Nutrition and Health

São Francisco Xavier Street, 900, João Lyra Filho Pavilion, second floor - Maracanã, Rio de Janeiro – Rio de Janeiro, Brazil, Zip Code 20550-000.

Flavia S. Barbosa, Universidade do Estado do Rio de Janeiro

 Universidade do Estado do Rio de Janeiro

Nutrition Institute

Department Social Nutrition

São Francisco Xavier Street, 900, João Lyra Filho Pavilion, second floor - Maracanã, Rio de Janeiro – Rio de Janeiro, Brazil, Zip Code 20550-000.

Marcos Fleury, Universidade Federal do Rio de Janeiro

Universidade Federal do Rio de Janeiro

Pharmacy College

Laboratory Clinical Analysis

Carlos Chagas Filho Avenue, Block K, Room 50, Ilha do Fundão, Cidade Universitária, Rio de Janeiro - RJ, Brazil. Zip Code 21941-590.

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Published

2022-08-12

How to Cite

Cordovil, K., Crivelli, M. ., Calixto Lima, L. ., S. Barbosa, F., & Fleury, M. (2022). Predictive Equations Overestimated the Rest Energy Expenditure by Indirect Calorimetry in Adults with Sickle Cell Disease. The North African Journal of Food and Nutrition Research, 6(14), 94–106. https://doi.org/10.51745/najfnr.6.14.94-106
Received 2022-03-06
Accepted 2022-06-17
Published 2022-08-12