Randomized, placebo-controlled pilot study investigating the effects of <i>Laurus nobilis</i> tea on lipid profiles and oxidative stress biomarkers in healthy North African volunteers

Chahra Chbili; Sawssen  Mrad; Hajer Graiet; Mejda Selmi; Jihene Maatoug; Maher Maoua; Lamia Abdellaoui; Nejib Mrizek; Manel Nouira; Maha Ben Fredj; Helmi Ben Saad

doi:10.51745/najfnr.8.17.86-98

Human and Clinical Nutrition Functional and Novel Foods

Chahra Chbili ⁽¹⁾ , Sawssen Mrad ⁽²⁾ , Hajer Graiet ⁽³⁾ , Mejda Selmi ⁽⁴⁾ , Jihene Maatoug ⁽⁵⁾ , Maher Maoua ⁽⁶⁾ , Lamia Abdellaoui ⁽⁷⁾ , Nejib Mrizek ⁽⁸⁾ , Manel Nouira ⁽⁹⁾ , Maha Ben Fredj ⁽¹⁰⁾ , Helmi Ben Saad ⁽¹¹⁾

(1) University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse , Tunisia

(2) University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse , Tunisia

(3) University of Sousse, Faculty of Medicine Ibn El Jazzar , Tunisia

(4) University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar , Tunisia

(5) University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Hospital Farhat Hached, Department of Epidemiology. Street Mohamed El Karoui, 4000, Sousse , Tunisia

(6) University of Sousse, Faculty of Medicine Ibn El Jazzar. University of Sousse, Hospital Farhat Hached, Occupational Medicine Department. Street Mohamed El Karoui, 4000, Sousse , Tunisia

(7) University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar , Tunisia

(8) University of Sousse, Faculty of Medicine Ibn El Jazzar. University of Sousse, Hospital Farhat Hached, Occupational Medicine Department. Street Mohamed El Karoui, 4000, Sousse , Tunisia

(9) University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar , Tunisia

(10) University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar , Tunisia

(11) University of Sousse, Hospital Farhat Hached, Research laboratory “Heart failure, LR12SP09”, Street Mohamed El Karoui, 4000, Sousse. University of Sousse, Hospital Farhat Hached, Department of Physiology and Functional Explorations, Street Mohamed El Karoui, 4000, Sousse , Tunisia

https://doi.org/10.51745/najfnr.8.17.86-98

Issue
Vol. 8 No. 17 (2024): January - June, 2024

Submitted
December 3, 2023

Published
April 4, 2024

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Abstract

Background. Laurus-nobilis (Ln) is an evergreen tree from the Lauraceae family, widely utilized for its culinary and medicinal purposes. Aims. This study aims to investigate the effects of Ln-tea (Lnt) consumption on lipid profiles and oxidant/antioxidant stress biomarkers in healthy volunteers. Methods. A randomized, double-blind, placebo-controlled trial (PACTR202205671550114) was conducted involving healthy volunteers. Participants (n=62) were randomly assigned to either the experimental-group (EG, n=31), receiving Lnt, or the control-group (CG, n=31), receiving a placebo tea. The regimen was administered once daily for ten consecutive days. Blood samples were collected from each participant on two occasions: one day before the study (Day1) and one day after its completion (Day11). These samples underwent analysis for lipid data, including cholesterol, triglycerides, high- and low- density-lipoprotein-cholesterol (HDL-C, LDL-C, respectively), and low-density-lipoprotein-receptor (LDL-R). Additionally, oxidant/antioxidant stress biomarkers, such as superoxide-dismutase, uric-acid, and carbonylated-proteins, were assessed. Results. Data from seven participants (one from the EG, and six from the CG) were excluded from the final statistical analysis, resulting in 55 volunteers completing the study (30 in the EG, 25 in the CG). The two groups exhibited comparable demographic and clinical characteristics. In the EG, LDL-C decreased by 0.42 while HDL-C and LDL-R increased by 0.18 mmol/L and 189.45 pg/mL, respectively, compared to Day1. On Day11, the EG displayed lower LDL-C value and higher values of HDL-C and LDL-R compared to the CG. Significant interactive effects of the groups (2) vs. days (2) were observed for LDL-C, HDL-C, and LDL-R. No significant changes in oxidant/antioxidant stress biomarkers were noted between Day1 and Day11 in both groups. However, the EG showed higher levels of superoxide-dismutase compared to the CG on Day 11. Significant interactive effects of the groups (2) vs. days (2) were noted for superoxide-dismutase and carbonylated-proteins. Conclusions. Lnt infusion showed potential in modulating LDL-R activity levels, accompanied by elevated antioxidant activity.

Keywords: Laurus, oxidative stress, plant extracts, therapeutic use, tea.

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Chahra Chbili

University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse

chahrachbili@yahoo.fr (Primary Contact)

Sawssen Mrad

University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse

Hajer Graiet

University of Sousse, Faculty of Medicine Ibn El Jazzar

Mejda Selmi

University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar

Jihene Maatoug

University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Hospital Farhat Hached, Department of Epidemiology. Street Mohamed El Karoui, 4000, Sousse

Maher Maoua

University of Sousse, Faculty of Medicine Ibn El Jazzar. University of Sousse, Hospital Farhat Hached, Occupational Medicine Department. Street Mohamed El Karoui, 4000, Sousse

Lamia Abdellaoui

University of Sousse, Faculty of Medicine. Laboratory of Biochemistry, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar

Nejib Mrizek

University of Sousse, Faculty of Medicine Ibn El Jazzar. University of Sousse, Hospital Farhat Hached, Occupational Medicine Department. Street Mohamed El Karoui, 4000, Sousse

Manel Nouira

University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar

Maha Ben Fredj

University of Sousse, Faculty of Medicine Ibn El Jazzar, Metabolic Biophysics, Applied Pharmacology Laboratory, Street Mohamed El Kaoui, 4000, Sousse. University of Sousse, Faculty of Medicine Ibn El Jazzar

Helmi Ben Saad

University of Sousse, Hospital Farhat Hached, Research laboratory “Heart failure, LR12SP09”, Street Mohamed El Karoui, 4000, Sousse. University of Sousse, Hospital Farhat Hached, Department of Physiology and Functional Explorations, Street Mohamed El Karoui, 4000, Sousse

Chbili, C., Mrad, S. ., Graiet, H., Selmi, M., Maatoug, J., Maoua, M., Abdellaoui, L., Mrizek, N., Nouira, M., Ben Fredj, M., & Ben Saad, H. (2024). Randomized, placebo-controlled pilot study investigating the effects of <i>Laurus nobilis</i> tea on lipid profiles and oxidative stress biomarkers in healthy North African volunteers. The North African Journal of Food and Nutrition Research, 8(17), 86–98. https://doi.org/10.51745/najfnr.8.17.86-98

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Received 2023-12-03
Accepted 2024-03-13
Published 2024-04-04

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